virological response and muscular adverse events during long-term clevudine therapy in chronic hepatitis b patients
نویسندگان
چکیده
background recently, several reports issued clevudine induced myopathy in the long term use. objectives the aim of this study was to investigate antiviral effects and adverse events of clevudine monotherapy in patients with chronic hepatitis b (chb). patients and methods the subjects were 110 treatment-naïve chb patients. they were treated with 30 mg clevudine/day for more than six months. virological and biochemical tests, including that for serum creatine kinase (ck), were monitored at baseline and at 3-month intervals during treatment period. results in hbeag-positive patients, the cumulative rates of virological response were 74.0 %, 68.5 %, and 67.3 % after one, two, and three years of clevudine treatment, respectively. cumulative rates of hbeag loss or seroconversion were 17.8 %, 30 %, and 31.5 % after one, two and, three years of clevudine treatment, respectively. in hbeag-negative patients, the cumulative rates of virological response were 97.3 %, 100 %, and 94.6 %, respectively. virological breakthrough occurred in 27 patients. the rtm204i mutation in hbv polymerase was predominantly detected. muscular adverse events were observed in 15 patients. all patients with myopathy recovered after the cessation of clevudine monotherapy. fluctuations in ck level during the clevudine treatment period were frequently observed irrespective of development of myopathy. multiple episodes of ck elevation were significantly related to the development of myopathy. conclusions long-term clevudine monotherapy is effective for suppression of serum hbv dna level and normalization of serum alanine amino transaminase levels, but associated with occurrence of rtm204i mutation. clevudine-induced muscular adverse events are not uncommon, although they are totally reversible after cessation of the treatment. muscular adverse events and serum ck level should be carefully monitored during long-term treatment with clevudine.
منابع مشابه
Virological Response and Muscular Adverse Events during Long-Term Clevudine Therapy in Chronic Hepatitis B Patients
BACKGROUND Recently, several reports issued clevudine induced myopathy in the long term use. OBJECTIVES The aim of this study was to investigate antiviral effects and adverse events of clevudine monotherapy in patients with chronic hepatitis B (CHB). PATIENTS AND METHODS The subjects were 110 treatment-naïve CHB patients. They were treated with 30 mg clevudine/day for more than six months. ...
متن کاملLong-Term Treatment Efficacy and Safety of Clevudine Therapy in Naïve Patients with Chronic Hepatitis B
BACKGROUND/AIMS Clevudine (CLV) has potent antiviral activity against chronic hepatitis B (CHB) virus infection. The long-term efficacy and safety of CLV therapy in naïve patients with CHB were investigated. METHODS In this retrospective study, 152 naïve Korean patients with CHB who received 30 mg of CLV once daily for at least 12 months were investigated. RESULTS The cumulative rates at mo...
متن کاملLong-term virological outcome in chronic hepatitis B patients with a partial virological response to entecavir
BACKGROUND/AIMS The clinical outcome of patients with a partial virological response (PVR) to entecavir (ETV), in particular nucloes(t)ide analogue (NA)-experienced patients, has not been thoroughly investigated. The aim of the present study was to assess long-term outcomes in NA-naive and NA-experienced chronic hepatitis B patients with a PVR to ETV. METHODS Chronic hepatitis B patients trea...
متن کاملEvolution of hepatitis B virus during long-term therapy in patients with chronic hepatitis B.
BACKGROUND Long-term lamivudine (LAM), adefovir (ADV) and entecavir (ETV) treatment induce the emergence of drug-resistant hepatitis B virus (HBV) in patients with chronic hepatitis B infection. AIM To evaluate the LAM, ADV and ETV resistance mutations detected in our patient group. MATERIALS AND METHODS Twenty patients who had received at least two years of treatment with nucleoside/tide a...
متن کاملEvolution of hepatitis B virus during long-term therapy in patients with chronic hepatitis
Background. Long-term lamivudine (LAM), adefovir (ADV) and entecavir (ETV) treatment induce the emergence of drug-resistant hepatitis B virus (HBV) in patients with chronic hepatitis B infection. Aim. To evaluate the LAM, ADV and ETV resistance mutations detected in our patient group. Materials and methods. Twenty patients who had received at least two years of treatment with nucleoside/tide an...
متن کاملClevudine myopathy in patients with chronic hepatitis B.
Clevudine (L-FMAU) is a thymidine l-nucleoside analogue that was recently introduced for the treatment of chronic hepatitis B virus infection. Previous studies showed that clevudine has potent and sustained antiviral activity without causing viral resistance. No severe adverse event occurred during clinical trials. We describe two cases of drug-induced myopathy during long-term treatment of chr...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
hepatitis monthlyجلد ۱۳، شماره ۴، صفحات ۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023